Assay Detail
Binding
CHEMBL4184427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CaMK2alpha/beta in neonatal rat cortical neurons assessed as phospholamban phosphorylation after 4 hrs by Hoechst 33342 fluorescence-based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.74 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215300 | — | — | 1 | 6.92 |
| CHEMBL4210359 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215300 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4210359 | — | EC50 | = | 274.0 | nM | 6.56 |