Assay Detail
Functional
CHEMBL4184672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P3 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P5 receptor agonist chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 5.74 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205714 | — | — | 1 | 6.00 |
| CHEMBL4204437 | — | — | 1 | 5.90 |
| CHEMBL4207162 | — | — | 1 | 5.80 |
| CHEMBL4203755 | — | — | 1 | 5.80 |
| CHEMBL4205878 | — | — | 1 | 5.70 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.60 |
| CHEMBL4205124 | — | — | 1 | 5.40 |
| CHEMBL4205748 | — | — | 1 | - |
| CHEMBL4218296 | — | — | 1 | - |
| CHEMBL4208771 | — | — | 1 | - |
| CHEMBL4209307 | — | — | 1 | - |
| CHEMBL4217349 | — | — | 1 | - |
| CHEMBL4205225 | — | — | 1 | - |
| CHEMBL4210019 | — | — | 1 | - |
| CHEMBL4209494 | — | — | 1 | - |
| CHEMBL4208055 | — | — | 1 | - |
| CHEMBL4213894 | — | — | 1 | - |
| CHEMBL4218826 | — | — | 1 | - |
| CHEMBL4218094 | — | — | 1 | - |
| CHEMBL4217573 | — | — | 1 | - |
| CHEMBL4213167 | — | — | 1 | - |
| CHEMBL4205333 | — | — | 1 | - |
| CHEMBL4213649 | — | — | 1 | - |
| CHEMBL4210234 | — | — | 1 | - |
| CHEMBL4208787 | — | — | 1 | - |
| CHEMBL4204779 | — | — | 1 | - |
| CHEMBL4207361 | — | — | 1 | - |
| CHEMBL4210576 | — | — | 1 | - |
| CHEMBL4210080 | — | — | 1 | - |
| CHEMBL4215002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205714 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4204437 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4207162 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4203755 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4205878 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL314854 | FINGOLIMOD | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4205124 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4205748 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4206573 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4208771 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4209307 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4217349 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4205225 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4210019 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4209494 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4208055 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4213894 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4218826 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4218296 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4218094 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4217573 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4213167 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4205333 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4213649 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4210234 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4208787 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4204779 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL4207361 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4210576 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4210080 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4215002 | — | EC50 | > | 10000.0 | nM | - |