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Assay Detail

CHEMBL4184680

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Zika virus infected in human A549 cells preincubated for 5 hrs followed by compound wash measured after 48 hrs by viral plague-forming assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Zika virus
Cell Type A549
Confidence 1 — Organism
Curated By Intermediate

Target

Zika virus (CHEMBL4296612)
Type ORGANISM
Organism Zika virus

Publication

Identification of novel small-molecule inhibitors of Zika virus infection.
Micewicz ED, Khachatoorian R, French SW, Ruchala P.
Bioorg Med Chem Lett (2018) 28 : 452 -458
PubMed 29258771 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.03 9.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4207559 1 9.72
CHEMBL4214443 1 9.50
CHEMBL4214820 1 9.06
CHEMBL325795 S-ROLIPRAM 1 7.59
CHEMBL4212750 1 7.57
CHEMBL483688 1 7.36
CHEMBL63 ROLIPRAM 2.0 1 7.35
CHEMBL4204703 1 7.23
CHEMBL430893 (-)-ROLIPRAM 1 7.11
CHEMBL240624 PRELADENANT 3.0 1 6.87
CHEMBL1531435 1 6.79
CHEMBL4208511 1 6.74
CHEMBL177542 1 6.70
CHEMBL603830 DAXALIPRAM 2.0 1 6.11
CHEMBL113142 ZM-241385 1 5.97
CHEMBL4207134 1 5.78
CHEMBL136689 1 5.51
CHEMBL4212468 1 5.35
CHEMBL4202786 1 5.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4207559 IC50 = 0.1892 nM 9.72
CHEMBL4214443 IC50 = 0.3177 nM 9.50
CHEMBL4214820 IC50 = 0.87 nM 9.06
CHEMBL325795 S-ROLIPRAM IC50 = 25.8 nM 7.59
CHEMBL4212750 IC50 = 26.9 nM 7.57
CHEMBL483688 IC50 = 43.8 nM 7.36
CHEMBL63 ROLIPRAM IC50 = 44.6 nM 7.35
CHEMBL4204703 IC50 = 58.6 nM 7.23
CHEMBL430893 (-)-ROLIPRAM IC50 = 77.6 nM 7.11
CHEMBL240624 PRELADENANT IC50 = 136.1 nM 6.87
CHEMBL1531435 IC50 = 160.3 nM 6.79
CHEMBL4208511 IC50 = 182.0 nM 6.74
CHEMBL177542 IC50 = 200.9 nM 6.70
CHEMBL603830 DAXALIPRAM IC50 = 769.1 nM 6.11
CHEMBL113142 ZM-241385 IC50 = 1066.6 nM 5.97
CHEMBL4207134 IC50 = 1678.8 nM 5.78
CHEMBL136689 IC50 = 3062.0 nM 5.51
CHEMBL4212468 IC50 = 4477.1 nM 5.35
CHEMBL4202786 IC50 = 4943.1 nM 5.31