Assay Detail
Functional
CHEMBL4184762
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Agonist activity at human OTR expressed in CHO cells assessed as increase in calcium flux after 60 to 120 mins by fluo-4 dye based FLIPR assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hybrid peptide-small molecule oxytocin analogs are potent and selective agonists of the oxytocin receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 8.82 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439044 | — | — | 1 | 10.40 |
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 10.40 |
| CHEMBL4208981 | — | — | 1 | 9.36 |
| CHEMBL4204637 | — | — | 1 | 9.29 |
| CHEMBL4213896 | — | — | 1 | 9.22 |
| CHEMBL4206141 | — | — | 1 | 9.22 |
| CHEMBL4212399 | — | — | 1 | 9.11 |
| CHEMBL4216826 | — | — | 1 | 9.08 |
| CHEMBL4204502 | — | — | 1 | 8.89 |
| CHEMBL4203673 | — | — | 1 | 8.74 |
| CHEMBL4205163 | — | — | 1 | 8.74 |
| CHEMBL4205509 | — | — | 1 | 8.44 |
| CHEMBL4205128 | — | — | 1 | 8.28 |
| CHEMBL4207691 | — | — | 1 | 8.27 |
| CHEMBL4212247 | — | — | 1 | 8.17 |
| CHEMBL4217226 | — | — | 1 | 7.55 |
| CHEMBL4217353 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439044 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL395429 | OXYTOCIN | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4208981 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4204637 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4213896 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4206141 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4212399 | — | EC50 | = | 0.77 | nM | 9.11 |
| CHEMBL4216826 | — | EC50 | = | 0.83 | nM | 9.08 |
| CHEMBL4204502 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4203673 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4205163 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4205509 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4205128 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4207691 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4212247 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4217226 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4217353 | — | EC50 | = | 194.0 | nM | 6.71 |