Assay Detail
Binding
CHEMBL4184982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERCA1a (unknown origin) ATPase activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL3136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca<sup>2+</sup> pump inhibitor from marine cyanobacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.81 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.00 |
| CHEMBL4216774 | — | — | 1 | 7.77 |
| CHEMBL4207081 | — | — | 1 | 7.72 |
| CHEMBL480627 | CYCLOPIAZONIC ACID | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL4216774 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4207081 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL480627 | CYCLOPIAZONIC ACID | Ki | = | 1800.0 | nM | 5.75 |