Assay Detail
Functional
CHEMBL4185019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Target ROS to induce apoptosis and cell cycle arrest by 5,7-dimethoxy-1,4-naphthoquinone derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.38 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208719 | — | — | 1 | 5.42 |
| CHEMBL4218044 | — | — | 1 | 5.04 |
| CHEMBL4213121 | — | — | 1 | 4.82 |
| CHEMBL4217536 | — | — | 1 | 4.58 |
| CHEMBL4213659 | — | — | 1 | 4.28 |
| CHEMBL4203196 | — | — | 1 | 4.25 |
| CHEMBL4210196 | — | — | 1 | 4.21 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.17 |
| CHEMBL4205029 | — | — | 1 | 4.06 |
| CHEMBL4207407 | — | — | 1 | 4.03 |
| CHEMBL4203078 | — | — | 1 | 4.02 |
| CHEMBL4214301 | — | — | 1 | 4.02 |
| CHEMBL4209903 | — | — | 1 | 4.02 |
| CHEMBL4215721 | — | — | 1 | - |
| CHEMBL4206301 | — | — | 1 | - |
| CHEMBL4206970 | — | — | 1 | - |
| CHEMBL4212647 | — | — | 1 | - |
| CHEMBL4213797 | — | — | 1 | - |
| CHEMBL4206464 | — | — | 1 | - |
| CHEMBL4218195 | — | — | 1 | - |
| CHEMBL4210765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208719 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4218044 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4213121 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4217536 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL4213659 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4203196 | — | IC50 | = | 55900.0 | nM | 4.25 |
| CHEMBL4210196 | — | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL4205029 | — | IC50 | = | 86700.0 | nM | 4.06 |
| CHEMBL4207407 | — | IC50 | = | 93100.0 | nM | 4.03 |
| CHEMBL4203078 | — | IC50 | = | 96100.0 | nM | 4.02 |
| CHEMBL4214301 | — | IC50 | = | 95500.0 | nM | 4.02 |
| CHEMBL4209903 | — | IC50 | = | 95800.0 | nM | 4.02 |
| CHEMBL4215721 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4206301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4206970 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4212647 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4213797 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4206464 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4218195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4210765 | — | IC50 | > | 100000.0 | nM | - |