Assay Detail
Functional
CHEMBL4185063
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Semisynthesis, cytotoxicity, antimalarial evaluation and structure-activity relationship of two series of triterpene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.07 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.79 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.81 |
| CHEMBL4216644 | — | — | 1 | 5.47 |
| CHEMBL607802 | — | — | 1 | 5.28 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 5.10 |
| CHEMBL4210469 | — | — | 1 | 5.05 |
| CHEMBL410525 | O-ACETYLURSOLIC ACID | — | 1 | 5.04 |
| CHEMBL2147688 | — | — | 1 | 5.04 |
| CHEMBL4216396 | — | — | 1 | 4.98 |
| CHEMBL571294 | — | — | 1 | 4.92 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.89 |
| CHEMBL611923 | — | — | 1 | 4.88 |
| CHEMBL4209684 | — | — | 1 | 4.87 |
| CHEMBL487887 | URSONIC ACID | — | 1 | 4.62 |
| CHEMBL4208831 | — | — | 1 | 4.53 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 4.30 |
| CHEMBL2147682 | — | — | 1 | 4.30 |
| CHEMBL4205923 | — | — | 1 | 4.24 |
| CHEMBL312687 | — | — | 1 | 4.18 |
| CHEMBL605530 | — | — | 1 | - |
| CHEMBL4218455 | — | — | 1 | - |
| CHEMBL4213811 | — | — | 1 | - |
| CHEMBL4217631 | — | — | 1 | - |
| CHEMBL376266 | METHYL BETULONATE | — | 1 | - |
| CHEMBL508907 | — | — | 1 | - |
| CHEMBL4212196 | — | — | 1 | - |
| CHEMBL4203723 | — | — | 1 | - |
| CHEMBL4216252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL4216644 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL607802 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL4210469 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL410525 | O-ACETYLURSOLIC ACID | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL2147688 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL4216396 | — | IC50 | = | 10390.0 | nM | 4.98 |
| CHEMBL571294 | — | IC50 | = | 12110.0 | nM | 4.92 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL611923 | — | IC50 | = | 13320.0 | nM | 4.88 |
| CHEMBL4209684 | — | IC50 | = | 13590.0 | nM | 4.87 |
| CHEMBL487887 | URSONIC ACID | IC50 | = | 24260.0 | nM | 4.62 |
| CHEMBL4208831 | — | IC50 | = | 29610.0 | nM | 4.53 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 50640.0 | nM | 4.30 |
| CHEMBL2147682 | — | IC50 | = | 50640.0 | nM | 4.30 |
| CHEMBL4205923 | — | IC50 | = | 57620.0 | nM | 4.24 |
| CHEMBL312687 | — | IC50 | = | 65500.0 | nM | 4.18 |
| CHEMBL605530 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4218455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4213811 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4217631 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL376266 | METHYL BETULONATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL508907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4212196 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4203723 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4216252 | — | IC50 | > | 100000.0 | nM | - |