Assay Detail
Binding
CHEMBL4185199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 in Plasmodium falciparum 3D7 nuclear extract using Ac-RGK(Ac)-AMC fluorogenic peptide as substrate preincubated for 1 hr followed by substrate addition measured after 10 min by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum 3D7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.07 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.05 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.48 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 214.7 | nM | 6.67 |