Assay Detail
Functional
CHEMBL4185201
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Antimalarial activity against Plasmodium falciparum infected in human erythrocytes preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.88 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.00 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.22 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 7.05 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 6.10 |
| CHEMBL4215938 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4215938 | — | IC50 | = | 900.0 | nM | 6.05 |