Assay Detail
Functional
CHEMBL4185403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.67 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164015 | — | — | 1 | 7.70 |
| CHEMBL4215403 | — | — | 1 | 7.44 |
| CHEMBL4214978 | — | — | 1 | 7.29 |
| CHEMBL4171228 | — | — | 1 | 7.28 |
| CHEMBL1957266 | — | — | 1 | 7.25 |
| CHEMBL4208405 | — | — | 1 | 7.19 |
| CHEMBL3581661 | — | — | 1 | 7.18 |
| CHEMBL4203276 | — | — | 1 | 7.16 |
| CHEMBL4208561 | — | — | 1 | 7.12 |
| CHEMBL4210754 | — | — | 1 | 6.91 |
| CHEMBL4210062 | — | — | 1 | 6.90 |
| CHEMBL4211972 | — | — | 1 | 6.86 |
| CHEMBL4203725 | — | — | 1 | 6.71 |
| CHEMBL4209113 | — | — | 1 | 6.69 |
| CHEMBL4213494 | — | — | 1 | 6.66 |
| CHEMBL2017291 | — | — | 1 | 6.64 |
| CHEMBL4210981 | — | — | 1 | 6.63 |
| CHEMBL1232461 | MOLIBRESIB | 2.0 | 1 | 6.62 |
| CHEMBL4218757 | — | — | 1 | 6.61 |
| CHEMBL4212515 | — | — | 1 | 6.58 |
| CHEMBL4211497 | — | — | 1 | 6.43 |
| CHEMBL4207609 | — | — | 1 | 6.42 |
| CHEMBL4218866 | — | — | 1 | 6.31 |
| CHEMBL4207729 | — | — | 1 | 6.21 |
| CHEMBL4209937 | — | — | 1 | 6.18 |
| CHEMBL4215941 | — | — | 1 | 6.15 |
| CHEMBL4202675 | — | — | 1 | 6.14 |
| CHEMBL4207024 | — | — | 1 | 6.01 |
| CHEMBL4210448 | — | — | 1 | 5.94 |
| CHEMBL4212636 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164015 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4215403 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4214978 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4171228 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1957266 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4208405 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3581661 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4203276 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4208561 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4210754 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4210062 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4211972 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4203725 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4209113 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL4213494 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2017291 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL4210981 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1232461 | MOLIBRESIB | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL4218757 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4212515 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL4211497 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL4207609 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4218866 | — | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL4207729 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL4209937 | — | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL4215941 | — | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL4202675 | — | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL4207024 | — | IC50 | = | 971.0 | nM | 6.01 |
| CHEMBL4210448 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4212636 | — | IC50 | = | 9271.0 | nM | 5.03 |
| CHEMBL4215450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4216942 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4205577 | — | IC50 | - | — | - | |
| CHEMBL4217058 | — | IC50 | > | 10000.0 | nM | - |