Assay Detail
ADMET
CHEMBL4185641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Characterization of a highly selective inhibitor of the Aurora kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.54 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3969370 | — | — | 1 | 7.80 |
| CHEMBL4206831 | — | — | 1 | 6.60 |
| CHEMBL3393498 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3969370 | — | IC50 | = | 15.81 | nM | 7.80 |
| CHEMBL4206831 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL3393498 | — | IC50 | = | 5864.0 | nM | 5.23 |