Assay Detail
Binding
CHEMBL4185648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged human PLK4 (1 to 836 residues) by Lanthascreen binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK4 (CHEMBL3788) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of a highly selective inhibitor of the Aurora kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.23 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3969370 | — | — | 1 | 7.36 |
| CHEMBL4206831 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3969370 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL4206831 | — | IC50 | = | 82.0 | nM | 7.09 |