Assay Detail
Binding
CHEMBL4186280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system using TK-substrate after 25 mins by HTRF KinEASE-TK assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress of Small-Molecule Epidermal Growth Factor Receptor (EGFR) Inhibitors against C797S Resistance in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.50 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4090601 | — | — | 1 | 7.80 |
| CHEMBL4094959 | — | — | 1 | 7.46 |
| CHEMBL4095447 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4090601 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4094959 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4095447 | — | IC50 | = | 58.0 | nM | 7.24 |