Assay Detail
Binding
CHEMBL4186281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-fused human EGFR cytoplasmic domain T790M/C797S mutant expressed in baculovirus expression system using TK-substrate after 20 mins by HTRF KinEASE-TK assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Recent Progress of Small-Molecule Epidermal Growth Factor Receptor (EGFR) Inhibitors against C797S Resistance in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.66 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095447 | — | — | 1 | 8.72 |
| CHEMBL4094959 | — | — | 1 | 8.60 |
| CHEMBL4090601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095447 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4094959 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4090601 | — | IC50 | < | 1.0 | nM | - |