Assay Detail
Binding
CHEMBL4186285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human EGFR d746-750/T790M/C797S mutant using poly-Glu-Tyr (4:1) as substrate after 2 hrs in presence of [gamma-33P]-ATP by filter-binding method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Recent Progress of Small-Molecule Epidermal Growth Factor Receptor (EGFR) Inhibitors against C797S Resistance in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.40 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218431 | — | — | 1 | 7.77 |
| CHEMBL4207984 | — | — | 1 | 7.64 |
| CHEMBL4214588 | — | — | 1 | 7.34 |
| CHEMBL1328065 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218431 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4207984 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4214588 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1328065 | — | IC50 | = | 149.0 | nM | 6.83 |