Assay Detail
Binding
CHEMBL4186302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Clostridium perfringenes neuraminidase activity using 4-methylumbelliferyl-1-alpha-D-N-acetylneuramic acid sodium salt hydrate as substrate by fluorescence based assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium perfringens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of novel oseltamivir derivatives as potent neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.32 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220445 | — | — | 1 | 9.30 |
| CHEMBL81717 | — | — | 1 | 9.30 |
| CHEMBL2114178 | — | — | 1 | 9.30 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 9.00 |
| CHEMBL311288 | — | — | 1 | 9.00 |
| CHEMBL310004 | — | — | 1 | 9.00 |
| CHEMBL315261 | — | — | 1 | 9.00 |
| CHEMBL311205 | — | — | 1 | 8.70 |
| CHEMBL81790 | — | — | 1 | 8.52 |
| CHEMBL309834 | — | — | 1 | 8.52 |
| CHEMBL112356 | — | — | 1 | 8.22 |
| CHEMBL3220444 | — | — | 1 | 8.00 |
| CHEMBL320978 | — | — | 1 | 7.96 |
| CHEMBL420120 | — | — | 1 | 7.92 |
| CHEMBL79499 | — | — | 1 | 7.92 |
| CHEMBL430814 | — | — | 1 | 7.80 |
| CHEMBL54479 | — | — | 1 | 7.66 |
| CHEMBL440151 | — | — | 1 | 7.19 |
| CHEMBL113102 | — | — | 1 | 7.07 |
| CHEMBL112184 | — | — | 1 | 7.05 |
| CHEMBL81083 | — | — | 1 | 7.05 |
| CHEMBL312637 | — | — | 1 | 7.00 |
| CHEMBL113191 | — | — | 1 | 7.00 |
| CHEMBL3220446 | — | — | 1 | 6.75 |
| CHEMBL420495 | — | — | 1 | 6.75 |
| CHEMBL320788 | — | — | 1 | 6.70 |
| CHEMBL111857 | — | — | 1 | 6.70 |
| CHEMBL79524 | — | — | 1 | 6.70 |
| CHEMBL53049 | — | — | 1 | 6.65 |
| CHEMBL298659 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220445 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2114178 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL81717 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL311288 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL310004 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL315261 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL311205 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL81790 | — | IC50 | = | 2.999 | nM | 8.52 |
| CHEMBL309834 | — | IC50 | = | 2.999 | nM | 8.52 |
| CHEMBL112356 | — | IC50 | = | 5.998 | nM | 8.22 |
| CHEMBL3220444 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL320978 | — | IC50 | = | 10.99 | nM | 7.96 |
| CHEMBL420120 | — | IC50 | = | 11.99 | nM | 7.92 |
| CHEMBL79499 | — | IC50 | = | 11.99 | nM | 7.92 |
| CHEMBL430814 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL54479 | — | IC50 | = | 21.98 | nM | 7.66 |
| CHEMBL440151 | — | IC50 | = | 65.01 | nM | 7.19 |
| CHEMBL113102 | — | IC50 | = | 84.92 | nM | 7.07 |
| CHEMBL81083 | — | IC50 | = | 89.95 | nM | 7.05 |
| CHEMBL112184 | — | IC50 | = | 89.95 | nM | 7.05 |
| CHEMBL312637 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL113191 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3220446 | — | IC50 | = | 179.89 | nM | 6.75 |
| CHEMBL420495 | — | IC50 | = | 179.89 | nM | 6.75 |
| CHEMBL320788 | — | IC50 | = | 199.99 | nM | 6.70 |
| CHEMBL111857 | — | IC50 | = | 199.99 | nM | 6.70 |
| CHEMBL79524 | — | IC50 | = | 199.99 | nM | 6.70 |
| CHEMBL53049 | — | IC50 | = | 224.91 | nM | 6.65 |
| CHEMBL298659 | — | IC50 | = | 529.66 | nM | 6.28 |
| CHEMBL310217 | — | IC50 | = | 619.44 | nM | 6.21 |
| CHEMBL54806 | — | IC50 | = | 1999.86 | nM | 5.70 |
| CHEMBL112581 | — | IC50 | = | 2697.74 | nM | 5.57 |
| CHEMBL331151 | — | IC50 | = | 3999.45 | nM | 5.40 |
| CHEMBL320496 | — | IC50 | = | 6397.35 | nM | 5.19 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 61100.0 | nM | 4.21 |