Assay Detail
Binding
CHEMBL4186501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNAP (unknown origin) using PPi as substrate
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alkaline phosphatase, tissue-nonspecific isozyme (CHEMBL5979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.89 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1569928 | — | — | 1 | 8.22 |
| CHEMBL569639 | — | — | 1 | 8.22 |
| CHEMBL4214913 | — | — | 1 | 7.85 |
| CHEMBL567850 | — | — | 1 | 7.82 |
| CHEMBL4208605 | — | — | 1 | 7.80 |
| CHEMBL4217036 | — | — | 1 | 7.72 |
| CHEMBL4213116 | — | — | 1 | 7.64 |
| CHEMBL4215759 | — | — | 1 | 7.58 |
| CHEMBL4216295 | — | — | 1 | 7.42 |
| CHEMBL1569953 | — | — | 1 | 7.37 |
| CHEMBL4206067 | — | — | 1 | 7.19 |
| CHEMBL4216888 | — | — | 1 | 7.14 |
| CHEMBL4217814 | — | — | 1 | 7.14 |
| CHEMBL4214312 | — | — | 1 | 7.14 |
| CHEMBL4210692 | — | — | 1 | 7.08 |
| CHEMBL4205359 | — | — | 1 | 6.96 |
| CHEMBL4217588 | — | — | 1 | 6.92 |
| CHEMBL4210124 | — | — | 1 | 6.88 |
| CHEMBL4202840 | — | — | 1 | 6.87 |
| CHEMBL4215202 | — | — | 1 | 6.83 |
| CHEMBL4217835 | — | — | 1 | 6.80 |
| CHEMBL4217772 | — | — | 1 | 6.75 |
| CHEMBL4213236 | — | — | 1 | 6.74 |
| CHEMBL4213086 | — | — | 1 | 6.71 |
| CHEMBL4209321 | — | — | 1 | 6.70 |
| CHEMBL4216913 | — | — | 1 | 6.51 |
| CHEMBL4204021 | — | — | 1 | 6.49 |
| CHEMBL4217934 | — | — | 1 | 6.37 |
| CHEMBL4204197 | — | — | 1 | 6.17 |
| CHEMBL4205652 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1569928 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL569639 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4214913 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL567850 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4208605 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4217036 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4213116 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4215759 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4216295 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1569953 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4206067 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4216888 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4217814 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4214312 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4210692 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4205359 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4217588 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4210124 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4202840 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4215202 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4217835 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4217772 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4213236 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4213086 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4209321 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL4216913 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4204021 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL4217934 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL4204197 | — | IC50 | = | 671.0 | nM | 6.17 |
| CHEMBL4205652 | — | IC50 | = | 876.0 | nM | 6.06 |
| CHEMBL4212628 | — | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL4212086 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4206103 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4209407 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL1566142 | — | IC50 | = | 10300.0 | nM | 4.99 |