Assay Detail
Binding
CHEMBL4186848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MLL1-WDR5 (unknown origin) protein-protein interaction by fluorescence-labeled Ac-ARA peptide tracer based fluorescence polarization assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Histone-lysine N-methyltransferase 2A/WDR5 (CHEMBL3883320) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.05 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3798088 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3798088 | — | IC50 | = | 0.9 | nM | 9.05 |