Assay Detail
Binding
CHEMBL4186928
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Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in CHO-K1 cell membranes after 60 mins by microbeta scintillation counting analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-HT1A and 5-HT2A receptors affinity, docking studies and pharmacological evaluation of a series of 8-acetyl-7-hydroxy-4-methylcoumarin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.40 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218720 | — | — | 1 | 9.30 |
| CHEMBL4215022 | — | — | 1 | 9.22 |
| CHEMBL4213170 | — | — | 1 | 9.05 |
| CHEMBL4217736 | — | — | 1 | 9.05 |
| CHEMBL4218830 | — | — | 1 | 9.00 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.85 |
| CHEMBL4207177 | — | — | 1 | 8.82 |
| CHEMBL4209403 | — | — | 1 | 8.70 |
| CHEMBL4214598 | — | — | 1 | 8.60 |
| CHEMBL4215550 | — | — | 1 | 8.46 |
| CHEMBL4202831 | — | — | 1 | 8.43 |
| CHEMBL4212058 | — | — | 1 | 8.27 |
| CHEMBL4207990 | — | — | 1 | 8.06 |
| CHEMBL4207585 | — | — | 1 | 7.96 |
| CHEMBL4213789 | — | — | 1 | 7.85 |
| CHEMBL4212943 | — | — | 1 | 7.30 |
| CHEMBL4210596 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218720 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4215022 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4213170 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4217736 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4218830 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL39 | SEROTONIN | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4207177 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4209403 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4214598 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4215550 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4202831 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4212058 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL4207990 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL4207585 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4213789 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4212943 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4210596 | — | Ki | = | 1350.0 | nM | 5.87 |