Assay Detail
Binding
CHEMBL4186984
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Displacement of 125I-sauvagine from CRF1 receptor in human IMR-32 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.61 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293228 | — | — | 1 | 8.70 |
| CHEMBL303380 | — | — | 1 | 8.70 |
| CHEMBL304272 | — | — | 1 | 8.52 |
| CHEMBL304335 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293228 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL303380 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL304272 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL304335 | — | Ki | = | 3.0 | nM | 8.52 |