Assay Detail
Functional
CHEMBL4187321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structural optimization of N1-aryl-benzimidazoles for the discovery of new non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.77 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.40 |
| CHEMBL3114032 | — | — | 1 | 7.70 |
| CHEMBL4203336 | — | — | 1 | 7.62 |
| CHEMBL4218333 | — | — | 1 | 7.55 |
| CHEMBL3114049 | — | — | 1 | 7.40 |
| CHEMBL4211084 | — | — | 1 | 7.29 |
| CHEMBL3114034 | — | — | 1 | 7.22 |
| CHEMBL4211907 | — | — | 1 | 7.03 |
| CHEMBL3114045 | — | — | 1 | 6.96 |
| CHEMBL4218422 | — | — | 1 | 6.92 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.75 |
| CHEMBL4207026 | — | — | 1 | 6.70 |
| CHEMBL4202681 | — | — | 1 | 6.63 |
| CHEMBL4204242 | — | — | 1 | 6.60 |
| CHEMBL4210982 | — | — | 1 | 6.10 |
| CHEMBL3114057 | — | — | 1 | 6.06 |
| CHEMBL4205972 | — | — | 1 | 5.96 |
| CHEMBL4213853 | — | — | 1 | 5.81 |
| CHEMBL4211390 | — | — | 1 | 5.57 |
| CHEMBL4203211 | — | — | 1 | 5.17 |
| CHEMBL4214858 | — | — | 1 | - |
| CHEMBL4216358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3114032 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4203336 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4218333 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3114049 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4211084 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3114034 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4211907 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3114045 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4218422 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4207026 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4202681 | — | EC50 | = | 235.0 | nM | 6.63 |
| CHEMBL4204242 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4210982 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3114057 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4205972 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4213853 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4211390 | — | EC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL4203211 | — | EC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL4214858 | — | EC50 | >= | 1060.0 | nM | - |
| CHEMBL4216358 | — | EC50 | >= | 9440.0 | nM | - |