Assay Detail
Binding
CHEMBL4187359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using P-NPP as substrate after 10 mins by Dixon plot analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.12 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4211682 | — | — | 1 | 5.68 |
| CHEMBL260553 | — | — | 1 | 5.57 |
| CHEMBL1782241 | COCHINCHINONE A | — | 1 | 5.51 |
| CHEMBL323197 | MANGOSTIN | — | 1 | 5.50 |
| CHEMBL4208135 | — | — | 1 | 5.47 |
| CHEMBL4214309 | — | — | 1 | 5.29 |
| CHEMBL4203265 | — | — | 1 | 5.05 |
| CHEMBL1782240 | — | — | 1 | 4.96 |
| CHEMBL4209191 | — | — | 1 | 4.70 |
| CHEMBL4217516 | — | — | 1 | 4.64 |
| CHEMBL4202640 | — | — | 1 | 4.53 |
| CHEMBL4218731 | — | — | 1 | 4.49 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | - |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4211682 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL260553 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL1782241 | COCHINCHINONE A | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL323197 | MANGOSTIN | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL4208135 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL4214309 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL4203265 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL1782240 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL4209191 | — | Ki | = | 19900.0 | nM | 4.70 |
| CHEMBL4217516 | — | Ki | = | 22900.0 | nM | 4.64 |
| CHEMBL4202640 | — | Ki | = | 29500.0 | nM | 4.53 |
| CHEMBL4218731 | — | Ki | = | 32700.0 | nM | 4.49 |
| CHEMBL307429 | DUVOGLUSTAT | Ki | - | — | - | |
| CHEMBL169 | URSOLIC ACID | Ki | - | — | - |