Assay Detail
Binding
CHEMBL4187638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH in mouse brain microsomes using OMP substrate by fluorescence based assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.77 | 7.96 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184238 | URB-597 | 1.0 | 2 | 7.96 |
| CHEMBL4204424 | — | — | 2 | 7.92 |
| CHEMBL4216368 | — | — | 1 | 6.46 |
| CHEMBL4215208 | — | — | 1 | 6.29 |
| CHEMBL2397148 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184238 | URB-597 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4204424 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4216368 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4215208 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2397148 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4204424 | — | Inhibition | > | 80.0 | % | - |
| CHEMBL184238 | URB-597 | Inhibition | > | 80.0 | % | - |