Fatty-acid amide hydrolase 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt O08914. Use UniProt O08914 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O08914 as the stable identity anchor, then attach disease evidence before program review.
Fatty-acid amide hydrolase 1
Review this target as Fatty-acid amide hydrolase 1, mapped to UniProt O08914. Sequence length is 579 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Fatty-acid amide hydrolase 1 as ChEMBL target CHEMBL3455, mapped to UniProt O08914. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Fatty-acid amide hydrolase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O08914 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Fatty-acid amide hydrolase 1 |
| UniProt Accession | O08914 |
| Component Type | Protein |
| Sequence Length | 579 aa |
Fatty-acid amide hydrolase 1
Review this target as Fatty-acid amide hydrolase 1, mapped to UniProt O08914. Sequence length is 579 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL113262 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL462609 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL112486 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL450965 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL2165084 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL2165083 | 9.74 | Ki | 0.18 | Preclinical |
| CHEMBL175854 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL4471658 | 9.64 | Ki | 0.23 | Preclinical |
| CHEMBL367966 | 9.55 | Ki | 0.28 | Preclinical |
| CHEMBL178398 | 9.54 | Ki | 0.29 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 27 | 59 | 6.5 |
| tissue-based format | 25 | 18 | 7.7 |
| assay format | 22 | 94 | 6.9 |
| cell-based format | 5 | 2 | 5.7 |
| single protein format | 5 | 40 | 7.8 |
| microsome format | 1 | 5 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| subcellular format | 2 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 4.4 |
| microsome format | 1 | 0 | — |