Compound Detail
CHEMBL462609
METHYL ICOSYLPHOSPHONOFLUORIDATE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL462609 |
| Name | METHYL ICOSYLPHOSPHONOFLUORIDATE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IRQAGEYFWAZZPI-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
378.6
MW (Da)
8.84
ALogP
2
HBA
0
HBD
26.3
PSA (Ų)
0.16
QED
1
Ro5 Violations
20
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3455 | IC50 | 10.0 | 10.0 | 0.1 | 1 |
| Monoglyceride lipase CHEMBL5774 | IC50 | 8.66 | 8.66 | 2.2 | 1 |
| Cannabinoid receptor 1 CHEMBL3037 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 0.1 | nM | 10.0 | Inhibition of FAAH-mediated [3H]anandamide hydrolysis in mouse brain | 18752948 |
| Monoglyceride lipase | IC50 | = | 2.2 | nM | 8.66 | Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain | 18752948 |
| Cannabinoid receptor 1 | IC50 | = | 20.0 | nM | 7.7 | Displacement of [3H]CP-55940 from CB1 receptor in mouse brain | 18752948 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18752948 | 10.1016/j.bmcl.2008.08.007 | Mus musculus | 6 |
| 18752948 | 10.1016/j.bmcl.2008.08.007 | Monoglyceride lipase | 1 |
| 18752948 | 10.1016/j.bmcl.2008.08.007 | Fatty-acid amide hydrolase 1 | 1 |
| 18752948 | 10.1016/j.bmcl.2008.08.007 | Cannabinoid receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine