Assay Detail
Binding
CHEMBL953297
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Inhibition of FAAH-mediated [3H]anandamide hydrolysis in mouse brain
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.33 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462609 | METHYL ICOSYLPHOSPHONOFLUORIDATE | — | 1 | 10.00 |
| CHEMBL450965 | — | — | 1 | 9.82 |
| CHEMBL499569 | — | — | 1 | 8.72 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | — | 1 | 8.70 |
| CHEMBL333149 | ISOPROPYL DODECYLFLUOROPHOSPHONATE | — | 1 | 8.52 |
| CHEMBL512224 | — | — | 1 | 8.52 |
| CHEMBL462582 | — | — | 1 | 7.92 |
| CHEMBL444970 | CHLORPHRIFOS OXON | — | 1 | 7.40 |
| CHEMBL462610 | — | — | 1 | 7.38 |
| CHEMBL23838 | PARAOXON | -1.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462609 | METHYL ICOSYLPHOSPHONOFLUORIDATE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL450965 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL499569 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL333149 | ISOPROPYL DODECYLFLUOROPHOSPHONATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL512224 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL462582 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL444970 | CHLORPHRIFOS OXON | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL462610 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL23838 | PARAOXON | IC50 | = | 540.0 | nM | 6.27 |