Assay Detail
Binding
CHEMBL953295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.40 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462582 | — | — | 1 | 10.15 |
| CHEMBL462610 | — | — | 1 | 9.85 |
| CHEMBL512224 | — | — | 1 | 9.55 |
| CHEMBL450965 | — | — | 1 | 9.51 |
| CHEMBL333149 | ISOPROPYL DODECYLFLUOROPHOSPHONATE | — | 1 | 9.10 |
| CHEMBL462609 | METHYL ICOSYLPHOSPHONOFLUORIDATE | — | 1 | 8.66 |
| CHEMBL444970 | CHLORPHRIFOS OXON | — | 1 | 8.00 |
| CHEMBL499569 | — | — | 1 | 6.85 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | — | 1 | 6.70 |
| CHEMBL23838 | PARAOXON | -1.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462582 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL462610 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL512224 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL450965 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL333149 | ISOPROPYL DODECYLFLUOROPHOSPHONATE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL462609 | METHYL ICOSYLPHOSPHONOFLUORIDATE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL444970 | CHLORPHRIFOS OXON | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL499569 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL97038 | DODECANESULFONYL FLUORIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL23838 | PARAOXON | IC50 | = | 2300.0 | nM | 5.64 |