Assay Detail
Binding
CHEMBL4187639
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Inhibition of FAAH in rat brain microsomes using OMP substrate by fluorescence based assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.35 | 8.36 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204424 | — | — | 2 | 8.36 |
| CHEMBL184238 | URB-597 | 1.0 | 2 | 7.92 |
| CHEMBL4216368 | — | — | 1 | 5.77 |
| CHEMBL2397148 | — | — | 1 | - |
| CHEMBL4215208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204424 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL184238 | URB-597 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4216368 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4204424 | — | Inhibition | > | 80.0 | % | - |
| CHEMBL184238 | URB-597 | Inhibition | > | 80.0 | % | - |
| CHEMBL2397148 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4215208 | — | IC50 | > | 10000.0 | nM | - |