Assay Detail
Functional
CHEMBL4188079
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Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.04 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.80 |
| CHEMBL4204815 | — | — | 1 | 5.68 |
| CHEMBL4203143 | — | — | 1 | 5.37 |
| CHEMBL4216487 | — | — | 1 | 5.37 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | 4.0 | 1 | 5.30 |
| CHEMBL4203627 | — | — | 1 | 5.28 |
| CHEMBL4216778 | — | — | 1 | 5.20 |
| CHEMBL4207030 | — | — | 1 | 5.12 |
| CHEMBL4206548 | — | — | 1 | 5.04 |
| CHEMBL4209889 | — | — | 1 | 4.97 |
| CHEMBL4216360 | — | — | 1 | 4.89 |
| CHEMBL4208496 | — | — | 1 | 4.72 |
| CHEMBL4204155 | — | — | 1 | 4.59 |
| CHEMBL4218274 | — | — | 1 | 4.52 |
| CHEMBL4209893 | — | — | 1 | 4.43 |
| CHEMBL4215830 | — | — | 1 | 4.35 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL4211392 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4204815 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4203143 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL4216487 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4203627 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL4216778 | — | IC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL4207030 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL4206548 | — | IC50 | = | 9090.0 | nM | 5.04 |
| CHEMBL4209889 | — | IC50 | = | 10710.0 | nM | 4.97 |
| CHEMBL4216360 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4208496 | — | IC50 | = | 19040.0 | nM | 4.72 |
| CHEMBL4204155 | — | IC50 | = | 25540.0 | nM | 4.59 |
| CHEMBL4218274 | — | IC50 | = | 30240.0 | nM | 4.52 |
| CHEMBL4209893 | — | IC50 | = | 37180.0 | nM | 4.43 |
| CHEMBL4215830 | — | IC50 | = | 44490.0 | nM | 4.35 |
| CHEMBL76 | CHLOROQUINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4211392 | — | IC50 | > | 100000.0 | nM | - |