Assay Detail
ADMET
CHEMBL4188520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length CDK1/Cyclin D3 expressed in baculovirus infected Sf9 insect cells using histone H1 substrate after 90 mins by ADP-Glo assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Cyclin-dependent kinase 1/ G1/S-specific cyclin-D3 (CHEMBL4296065) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design and synthesis of 4-(2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(piperazin-1-ylmethyl)pyridine-2-yl)pyrimidin-2-amine as a highly potent and selective cyclin-dependent kinases 4 and 6 inhibitors and the discovery of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.78 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 7.25 |
| CHEMBL4215702 | — | — | 1 | 6.45 |
| CHEMBL4205645 | — | — | 1 | 6.21 |
| CHEMBL4210028 | — | — | 1 | 6.13 |
| CHEMBL4209329 | — | — | 1 | 5.87 |
| CHEMBL4214566 | — | — | 1 | 5.84 |
| CHEMBL4208366 | — | — | 1 | 5.81 |
| CHEMBL4204961 | — | — | 1 | 5.81 |
| CHEMBL4210707 | — | — | 1 | 5.79 |
| CHEMBL4213109 | — | — | 1 | 5.73 |
| CHEMBL4207451 | — | — | 1 | 5.73 |
| CHEMBL4215568 | — | — | 1 | 5.72 |
| CHEMBL4211479 | — | — | 1 | 5.72 |
| CHEMBL4207804 | — | — | 1 | 5.68 |
| CHEMBL4212542 | — | — | 1 | 5.66 |
| CHEMBL4216447 | — | — | 1 | 5.64 |
| CHEMBL4207474 | — | — | 1 | 5.63 |
| CHEMBL4208172 | — | — | 1 | 5.57 |
| CHEMBL4209318 | — | — | 1 | 5.53 |
| CHEMBL4215126 | — | — | 1 | 5.53 |
| CHEMBL4211828 | — | — | 1 | 5.51 |
| CHEMBL4207966 | — | — | 1 | 5.47 |
| CHEMBL4217694 | — | — | 1 | 5.30 |
| CHEMBL4213847 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4215702 | — | IC50 | = | 353.9 | nM | 6.45 |
| CHEMBL4205645 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4210028 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL4209329 | — | IC50 | = | 1365.0 | nM | 5.87 |
| CHEMBL4214566 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4208366 | — | IC50 | = | 1535.0 | nM | 5.81 |
| CHEMBL4204961 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4210707 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4213109 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4207451 | — | IC50 | = | 1874.0 | nM | 5.73 |
| CHEMBL4215568 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4211479 | — | IC50 | = | 1914.0 | nM | 5.72 |
| CHEMBL4207804 | — | IC50 | = | 2075.0 | nM | 5.68 |
| CHEMBL4212542 | — | IC50 | = | 2189.0 | nM | 5.66 |
| CHEMBL4216447 | — | IC50 | = | 2268.0 | nM | 5.64 |
| CHEMBL4207474 | — | IC50 | = | 2333.0 | nM | 5.63 |
| CHEMBL4208172 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4209318 | — | IC50 | = | 2988.0 | nM | 5.53 |
| CHEMBL4215126 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4211828 | — | IC50 | = | 3072.0 | nM | 5.51 |
| CHEMBL4207966 | — | IC50 | = | 3363.0 | nM | 5.47 |
| CHEMBL4217694 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL4213847 | — | IC50 | = | 5562.0 | nM | 5.25 |