Assay Detail
Binding
CHEMBL4189176
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Inhibition of recombinant human CDK9/cyclin T1 using Ulight-CFFKNIVTPRTPPPSQGK-amide as substrate after 90 mins by fluorescence assay relative to control
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel CDK inhibitors via scaffold hopping from CAN508.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.67 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215205 | — | — | 1 | 6.82 |
| CHEMBL4208708 | — | — | 1 | 5.75 |
| CHEMBL4211730 | — | — | 1 | 5.62 |
| CHEMBL4214475 | — | — | 1 | 5.62 |
| CHEMBL4203594 | — | — | 1 | 5.46 |
| CHEMBL4213114 | — | — | 1 | 5.44 |
| CHEMBL4217525 | — | — | 1 | 4.98 |
| CHEMBL4216945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215205 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4208708 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4211730 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4214475 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4203594 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4213114 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4217525 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4216945 | — | IC50 | = | 529300.0 | nM | - |