Assay Detail
Functional
CHEMBL4189301
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Antiinflammatory activity in human whole blood assessed as inhibition of LPS-induced MCP1 release preincubated for 30 mins followed by LPS challenge measured after 24 hrs by immunoassay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.20 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213809 | — | — | 1 | 6.40 |
| CHEMBL4218735 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213809 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4218735 | — | IC50 | = | 1000.0 | nM | 6.00 |