Assay Detail
ADMET
CHEMBL4189612
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Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.69 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205925 | — | — | 1 | 6.43 |
| CHEMBL4209993 | — | — | 1 | 6.20 |
| CHEMBL4206683 | — | — | 1 | 5.75 |
| CHEMBL4078433 | — | — | 1 | 5.48 |
| CHEMBL4217240 | — | — | 1 | 5.47 |
| CHEMBL4216076 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205925 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL4209993 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL4206683 | — | IC50 | = | 1795.0 | nM | 5.75 |
| CHEMBL4078433 | — | IC50 | = | 3293.0 | nM | 5.48 |
| CHEMBL4217240 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL4216076 | — | IC50 | = | 16050.0 | nM | 4.79 |