Assay Detail
Functional
CHEMBL4189812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Ebolavirus like particle harboring EBOV VP40 assessed as inhibition of viral infection in human HeLa cells preincubated with host cells for 1 hrs followed by viral inoculation by beta-lactamse reporter assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.47 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 6.25 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 5.30 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1655 | TOREMIFENE | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 13700.0 | nM | 4.86 |