Assay Detail
Binding
CHEMBL4189817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminescence method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Pyrrolidine Derivatives of Budesonide as Long Acting Inhaled Corticosteroids for the Treatment of Pulmonary Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.55 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217175 | — | — | 1 | 8.80 |
| CHEMBL4204230 | — | — | 1 | 8.60 |
| CHEMBL4211724 | — | — | 1 | 8.49 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 8.32 |
| CHEMBL1676 | FLUTICASONE FUROATE | 4.0 | 1 | - |
| CHEMBL4217942 | — | — | 1 | - |
| CHEMBL4213791 | — | — | 1 | - |
| CHEMBL4214377 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217175 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4204230 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4211724 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1370 | BUDESONIDE | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1676 | FLUTICASONE FUROATE | EC50 | > | 3000.0 | nM | - |
| CHEMBL4217942 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4213791 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4214377 | — | EC50 | > | 3000.0 | nM | - |