Assay Detail
Binding
CHEMBL4190548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Halo-tagged histone H3.3 from Nluc-BRD4 (unknown origin) expressed in HEK293 cells using furimazine as substrate pretreated for 18 hrs followed by substrate addition measured within 5 mins by NanoBRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical probes and inhibitors of bromodomains outside the BET family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774655 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774655 | — | IC50 | = | 600.0 | nM | 6.22 |