Assay Detail
Binding
CHEMBL4190752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-Pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.86 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100116 | PENTAZOCINE | 4.0 | 1 | 8.27 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.18 |
| CHEMBL4218965 | — | — | 1 | 6.74 |
| CHEMBL4216717 | — | — | 1 | 6.72 |
| CHEMBL4209225 | — | — | 1 | 6.54 |
| CHEMBL4203694 | — | — | 1 | 6.41 |
| CHEMBL4206082 | — | — | 1 | 6.01 |
| CHEMBL4203850 | — | — | 1 | 6.00 |
| CHEMBL4212604 | — | — | 1 | - |
| CHEMBL4215892 | — | — | 1 | - |
| CHEMBL4216136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100116 | PENTAZOCINE | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL4218965 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL4216717 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL4209225 | — | Ki | = | 291.0 | nM | 6.54 |
| CHEMBL4203694 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL4206082 | — | Ki | = | 983.0 | nM | 6.01 |
| CHEMBL4203850 | — | Ki | = | 991.0 | nM | 6.00 |
| CHEMBL4212604 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4215892 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4216136 | — | Ki | > | 1000.0 | nM | - |