Assay Detail
Binding
CHEMBL4190753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma2 receptor in Sprague-Dawley rat liver membranes after 120 mins by scintillation counting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.99 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218965 | — | — | 1 | 7.35 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL4203694 | — | — | 1 | 6.99 |
| CHEMBL4216717 | — | — | 1 | 6.50 |
| CHEMBL4212604 | — | — | 1 | - |
| CHEMBL4215892 | — | — | 1 | - |
| CHEMBL4206082 | — | — | 1 | - |
| CHEMBL4209225 | — | — | 1 | - |
| CHEMBL4203850 | — | — | 1 | - |
| CHEMBL4216136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218965 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL4203694 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL4216717 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL4212604 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4215892 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4206082 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4209225 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4203850 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4216136 | — | Ki | > | 1000.0 | nM | - |