Assay Detail
Functional
CHEMBL4191437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.44 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217460 | — | — | 1 | 5.96 |
| CHEMBL4212239 | — | — | 1 | 5.75 |
| CHEMBL4207349 | — | — | 1 | 5.72 |
| CHEMBL4211706 | — | — | 1 | 5.72 |
| CHEMBL4208828 | — | — | 1 | 5.71 |
| CHEMBL4202829 | — | — | 1 | 5.71 |
| CHEMBL4218498 | — | — | 1 | 5.67 |
| CHEMBL4203949 | — | — | 1 | 5.53 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.49 |
| CHEMBL4204497 | — | — | 1 | 5.45 |
| CHEMBL4219005 | — | — | 1 | 5.44 |
| CHEMBL4217106 | — | — | 1 | 5.43 |
| CHEMBL4203676 | — | — | 1 | 5.43 |
| CHEMBL4214080 | — | — | 1 | 5.43 |
| CHEMBL4216678 | — | — | 1 | 5.42 |
| CHEMBL4206236 | — | — | 1 | 5.41 |
| CHEMBL4216595 | — | — | 1 | 5.41 |
| CHEMBL4206753 | — | — | 1 | 5.40 |
| CHEMBL4205391 | — | — | 1 | 5.39 |
| CHEMBL4211124 | — | — | 1 | 5.38 |
| CHEMBL4215549 | — | — | 1 | 5.37 |
| CHEMBL4207702 | — | — | 1 | 5.19 |
| CHEMBL4212503 | — | — | 1 | 5.17 |
| CHEMBL4210594 | — | — | 1 | 4.75 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217460 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4212239 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4207349 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4211706 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4208828 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4202829 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4218498 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4203949 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4204497 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL4219005 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL4217106 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4203676 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4214080 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL4216678 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL4206236 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4216595 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4206753 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL4205391 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4211124 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4215549 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL4207702 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4212503 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL4210594 | — | IC50 | = | 17610.0 | nM | 4.75 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 22520.0 | nM | 4.65 |