Assay Detail
ADMET
CHEMBL4191439
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Cytotoxicity against human 184B5 cells assessed as growth inhibition after 48 hrs by SRB assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | 184B5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.92 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216595 | — | — | 1 | 5.50 |
| CHEMBL4212239 | — | — | 1 | 5.38 |
| CHEMBL4217106 | — | — | 1 | 5.34 |
| CHEMBL4214080 | — | — | 1 | 5.31 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.30 |
| CHEMBL4205391 | — | — | 1 | 5.14 |
| CHEMBL4203949 | — | — | 1 | 5.10 |
| CHEMBL4204497 | — | — | 1 | 5.09 |
| CHEMBL4218498 | — | — | 1 | 5.09 |
| CHEMBL4208828 | — | — | 1 | 5.09 |
| CHEMBL4207349 | — | — | 1 | 4.92 |
| CHEMBL4203676 | — | — | 1 | 4.88 |
| CHEMBL4216678 | — | — | 1 | 4.88 |
| CHEMBL4202829 | — | — | 1 | 4.87 |
| CHEMBL4215549 | — | — | 1 | 4.79 |
| CHEMBL4211706 | — | — | 1 | 4.79 |
| CHEMBL4217460 | — | — | 1 | 4.78 |
| CHEMBL4210594 | — | — | 1 | 4.75 |
| CHEMBL4206236 | — | — | 1 | 4.75 |
| CHEMBL4212503 | — | — | 1 | 4.75 |
| CHEMBL4207702 | — | — | 1 | 4.74 |
| CHEMBL4219005 | — | — | 1 | 4.67 |
| CHEMBL4206753 | — | — | 1 | 4.55 |
| CHEMBL4211124 | — | — | 1 | 4.52 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216595 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4212239 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL4217106 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL4214080 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL4205391 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL4203949 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL4204497 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL4218498 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL4208828 | — | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL4207349 | — | IC50 | = | 12060.0 | nM | 4.92 |
| CHEMBL4203676 | — | IC50 | = | 13070.0 | nM | 4.88 |
| CHEMBL4216678 | — | IC50 | = | 13150.0 | nM | 4.88 |
| CHEMBL4202829 | — | IC50 | = | 13440.0 | nM | 4.87 |
| CHEMBL4215549 | — | IC50 | = | 16350.0 | nM | 4.79 |
| CHEMBL4211706 | — | IC50 | = | 16160.0 | nM | 4.79 |
| CHEMBL4217460 | — | IC50 | = | 16750.0 | nM | 4.78 |
| CHEMBL4210594 | — | IC50 | = | 17770.0 | nM | 4.75 |
| CHEMBL4206236 | — | IC50 | = | 17780.0 | nM | 4.75 |
| CHEMBL4212503 | — | IC50 | = | 17980.0 | nM | 4.75 |
| CHEMBL4207702 | — | IC50 | = | 18390.0 | nM | 4.74 |
| CHEMBL4219005 | — | IC50 | = | 21640.0 | nM | 4.67 |
| CHEMBL4206753 | — | IC50 | = | 28290.0 | nM | 4.55 |
| CHEMBL4211124 | — | IC50 | = | 30150.0 | nM | 4.52 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 76130.0 | nM | 4.12 |