Assay Detail
Functional
CHEMBL4191608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 isolate LAV infected in PHA-stimulated human PBMC assessed as reduction in p24 level after 7 days by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.79 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.14 |
| CHEMBL458904 | PATENTIFLORIN A | — | 1 | 6.97 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL458904 | PATENTIFLORIN A | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 532.0 | nM | 6.27 |