Assay Detail
Functional
CHEMBL4191767
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Antiviral activity against Influenza A virus A/PR/8/34 (H1N1) infected in MDCK cells measured after 48 hrs post infection by plaque reduction assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.03 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207632 | — | — | 1 | 6.75 |
| CHEMBL4216034 | — | — | 1 | 6.58 |
| CHEMBL4213039 | — | — | 1 | 5.92 |
| CHEMBL4218243 | — | — | 1 | 5.92 |
| CHEMBL4207915 | — | — | 1 | 5.75 |
| CHEMBL4210203 | — | — | 1 | 5.58 |
| CHEMBL4204841 | — | — | 1 | 5.09 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.00 |
| CHEMBL3110337 | — | — | 1 | 4.75 |
| CHEMBL4210552 | — | — | 1 | 4.72 |
| CHEMBL4209881 | — | — | 1 | 4.66 |
| CHEMBL4214527 | — | — | 1 | 4.62 |
| CHEMBL4213306 | — | — | 1 | 4.52 |
| CHEMBL3110332 | — | — | 1 | 4.39 |
| CHEMBL4216802 | — | — | 1 | 4.09 |
| CHEMBL4213962 | — | — | 1 | 4.07 |
| CHEMBL3110352 | — | — | 1 | 4.05 |
| CHEMBL4216808 | — | — | 1 | 4.03 |
| CHEMBL4211351 | — | — | 1 | - |
| CHEMBL4208962 | — | — | 1 | - |
| CHEMBL4211654 | — | — | 1 | - |
| CHEMBL4215438 | — | — | 1 | - |
| CHEMBL4205111 | — | — | 1 | - |
| CHEMBL4211583 | — | — | 1 | - |
| CHEMBL4216558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207632 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4216034 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4213039 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4218243 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4207915 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4210203 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4204841 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3110337 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4210552 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4209881 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4214527 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4213306 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3110332 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4216802 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL4213962 | — | EC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL3110352 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL4216808 | — | EC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL4211351 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4208962 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4211654 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4215438 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4205111 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4211583 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4216558 | — | EC50 | = | 101000.0 | nM | - |