Assay Detail
Binding
CHEMBL4192783
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Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 10.63 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205425 | — | — | 1 | 10.96 |
| CHEMBL4205954 | — | — | 1 | 10.88 |
| CHEMBL4209803 | — | — | 1 | 10.87 |
| CHEMBL4217663 | — | — | 1 | 10.85 |
| CHEMBL4210316 | — | — | 1 | 10.84 |
| CHEMBL4214430 | — | — | 1 | 10.78 |
| CHEMBL4213253 | — | — | 1 | 10.72 |
| CHEMBL4214707 | — | — | 1 | 10.68 |
| CHEMBL4210041 | — | — | 1 | 10.67 |
| CHEMBL4205144 | — | — | 1 | 10.59 |
| CHEMBL4218191 | — | — | 1 | 10.58 |
| CHEMBL4208866 | — | — | 1 | 10.55 |
| CHEMBL4209518 | — | — | 1 | 10.53 |
| CHEMBL4213792 | — | — | 1 | 9.29 |
| CHEMBL4214643 | — | — | 1 | - |
| CHEMBL4209728 | — | — | 1 | - |
| CHEMBL4212110 | — | — | 1 | - |
| CHEMBL4207230 | — | — | 1 | - |
| CHEMBL4207758 | — | — | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205425 | — | IC50 | = | 0.01095 | nM | 10.96 |
| CHEMBL4205954 | — | IC50 | = | 0.01323 | nM | 10.88 |
| CHEMBL4209803 | — | IC50 | = | 0.01352 | nM | 10.87 |
| CHEMBL4217663 | — | IC50 | = | 0.01415 | nM | 10.85 |
| CHEMBL4210316 | — | IC50 | = | 0.01441 | nM | 10.84 |
| CHEMBL4214430 | — | IC50 | = | 0.01672 | nM | 10.78 |
| CHEMBL4213253 | — | IC50 | = | 0.01893 | nM | 10.72 |
| CHEMBL4214707 | — | IC50 | = | 0.02094 | nM | 10.68 |
| CHEMBL4210041 | — | IC50 | = | 0.02158 | nM | 10.67 |
| CHEMBL4205144 | — | IC50 | = | 0.02592 | nM | 10.59 |
| CHEMBL4218191 | — | IC50 | = | 0.02621 | nM | 10.58 |
| CHEMBL4208866 | — | IC50 | = | 0.02836 | nM | 10.55 |
| CHEMBL4209518 | — | IC50 | = | 0.02938 | nM | 10.53 |
| CHEMBL4213792 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4214643 | — | IC50 | = | 9.26 | 10'5pM | - |
| CHEMBL4209728 | — | IC50 | = | 7.91 | 10'5pM | - |
| CHEMBL4212110 | — | IC50 | = | 9.14 | 10'5pM | - |
| CHEMBL4207230 | — | IC50 | = | 1.32 | 10'6pM | - |
| CHEMBL4207758 | — | IC50 | = | 1.36 | 10'6pM | - |
| CHEMBL502 | DONEPEZIL | IC50 | = | 3.46 | 10'3pM | - |