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Assay Detail

CHEMBL4193091

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Intermediate

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

One-pot three steps cascade synthesis of novel isoandrographolide analogues and their cytotoxic activity.
Kasemsuk T, Piyachaturawat P, Bunthawong R, Sirion U, Suksen K, Suksamrarn A, Saeeng R.
Eur J Med Chem (2017) 138 : 952 -963
PubMed 28755636 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.96 5.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123 ELLIPTECINE 1 5.69
CHEMBL4212081 1 5.28
CHEMBL4217293 1 5.25
CHEMBL4208210 1 5.23
CHEMBL4214077 1 5.21
CHEMBL4217544 1 5.21
CHEMBL4203597 1 5.19
CHEMBL4217001 1 5.07
CHEMBL186141 ANDROGRAPHOLIDE 3.0 1 5.03
CHEMBL4207960 1 4.76
CHEMBL4210153 1 4.62
CHEMBL4212858 1 4.59
CHEMBL4208909 1 4.58
CHEMBL4203849 1 4.56
CHEMBL4213130 1 4.52
CHEMBL4204138 1 4.52
CHEMBL4208728 1 -
CHEMBL4213835 1 -
CHEMBL4208480 1 -
CHEMBL4215808 1 -
CHEMBL4205297 1 -
CHEMBL4212334 1 -
CHEMBL4217012 1 -
CHEMBL4212023 1 -
CHEMBL4212585 1 -
CHEMBL4209566 1 -
CHEMBL4209158 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123 ELLIPTECINE IC50 = 2060.0 nM 5.69
CHEMBL4212081 IC50 = 5240.0 nM 5.28
CHEMBL4217293 IC50 = 5590.0 nM 5.25
CHEMBL4208210 IC50 = 5870.0 nM 5.23
CHEMBL4214077 IC50 = 6160.0 nM 5.21
CHEMBL4217544 IC50 = 6090.0 nM 5.21
CHEMBL4203597 IC50 = 6500.0 nM 5.19
CHEMBL4217001 IC50 = 8500.0 nM 5.07
CHEMBL186141 ANDROGRAPHOLIDE IC50 = 9340.0 nM 5.03
CHEMBL4207960 IC50 = 17470.0 nM 4.76
CHEMBL4210153 IC50 = 24120.0 nM 4.62
CHEMBL4212858 IC50 = 25720.0 nM 4.59
CHEMBL4208909 IC50 = 26230.0 nM 4.58
CHEMBL4203849 IC50 = 27680.0 nM 4.56
CHEMBL4213130 IC50 = 30120.0 nM 4.52
CHEMBL4204138 IC50 = 30250.0 nM 4.52
CHEMBL4208728 IC50 > 50000.0 nM -
CHEMBL4213835 IC50 > 50000.0 nM -
CHEMBL4208480 IC50 > 50000.0 nM -
CHEMBL4215808 IC50 > 50000.0 nM -
CHEMBL4205297 IC50 > 50000.0 nM -
CHEMBL4212334 IC50 > 50000.0 nM -
CHEMBL4217012 IC50 > 50000.0 nM -
CHEMBL4212023 IC50 > 50000.0 nM -
CHEMBL4212585 IC50 > 50000.0 nM -
CHEMBL4209566 IC50 > 50000.0 nM -
CHEMBL4209158 IC50 > 50000.0 nM -