Assay Detail
Binding
CHEMBL4193097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MMP9 (Ala20 to Asp707 residues) expressed in CHO cells using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.50 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267178 | — | — | 1 | 8.00 |
| CHEMBL4215396 | — | — | 1 | 5.06 |
| CHEMBL4207542 | — | — | 1 | 4.68 |
| CHEMBL4216220 | — | — | 1 | 4.61 |
| CHEMBL4216154 | — | — | 1 | 4.56 |
| CHEMBL4202778 | — | — | 1 | 4.47 |
| CHEMBL4213804 | — | — | 1 | 4.46 |
| CHEMBL4210262 | — | — | 1 | 4.44 |
| CHEMBL4214436 | — | — | 1 | 4.36 |
| CHEMBL4203206 | — | — | 1 | 4.32 |
| CHEMBL4218730 | — | — | 1 | 4.29 |
| CHEMBL4215930 | — | — | 1 | 4.29 |
| CHEMBL4206886 | — | — | 1 | 4.27 |
| CHEMBL4210975 | — | — | 1 | 4.26 |
| CHEMBL4211708 | — | — | 1 | 4.25 |
| CHEMBL4203717 | — | — | 1 | 4.24 |
| CHEMBL4212449 | — | — | 1 | 4.18 |
| CHEMBL4211189 | — | — | 1 | 4.14 |
| CHEMBL4202989 | — | — | 1 | 4.08 |
| CHEMBL4211258 | — | — | 1 | 4.08 |
| CHEMBL4211771 | — | — | 1 | 4.03 |
| CHEMBL4206821 | — | — | 1 | 4.02 |
| CHEMBL4203061 | — | — | 1 | - |
| CHEMBL4215193 | — | — | 1 | - |
| CHEMBL4214656 | — | — | 1 | - |
| CHEMBL12850 | DEHYDROABIETIC ACID | — | 1 | - |
| CHEMBL4202455 | — | — | 1 | - |
| CHEMBL4207344 | — | — | 1 | - |
| CHEMBL4211700 | — | — | 1 | - |
| CHEMBL4202528 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267178 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4215396 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4207542 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4216220 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL4216154 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL4202778 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL4213804 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL4210262 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL4214436 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL4203206 | — | IC50 | = | 48300.0 | nM | 4.32 |
| CHEMBL4218730 | — | IC50 | = | 51900.0 | nM | 4.29 |
| CHEMBL4215930 | — | IC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL4206886 | — | IC50 | = | 53600.0 | nM | 4.27 |
| CHEMBL4210975 | — | IC50 | = | 54600.0 | nM | 4.26 |
| CHEMBL4211708 | — | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL4203717 | — | IC50 | = | 57800.0 | nM | 4.24 |
| CHEMBL4212449 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL4211189 | — | IC50 | = | 72600.0 | nM | 4.14 |
| CHEMBL4202989 | — | IC50 | = | 82600.0 | nM | 4.08 |
| CHEMBL4211258 | — | IC50 | = | 83400.0 | nM | 4.08 |
| CHEMBL4211771 | — | IC50 | = | 93100.0 | nM | 4.03 |
| CHEMBL4206821 | — | IC50 | = | 95900.0 | nM | 4.02 |
| CHEMBL4203061 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4215193 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4214656 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL12850 | DEHYDROABIETIC ACID | IC50 | - | — | - | |
| CHEMBL4202455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4207344 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4211700 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4202528 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4207416 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4214716 | — | IC50 | > | 100000.0 | nM | - |