Assay Detail
Functional
CHEMBL4193440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinoline hybrids and their antiplasmodial and antimalarial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.90 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208882 | — | — | 1 | 7.92 |
| CHEMBL4211940 | — | — | 1 | 7.92 |
| CHEMBL4208489 | — | — | 1 | 7.92 |
| CHEMBL4206490 | — | — | 1 | 7.92 |
| CHEMBL4209744 | — | — | 1 | 7.92 |
| CHEMBL4206095 | — | — | 1 | 7.92 |
| CHEMBL4202867 | — | — | 1 | 7.92 |
| CHEMBL4208629 | — | — | 1 | 7.92 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.75 |
| CHEMBL5315124 | LEVOFLOXACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208882 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4211940 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4208489 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4206490 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4209744 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4206095 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4202867 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4208629 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL170 | QUININE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5315124 | LEVOFLOXACIN | IC50 | > | 20000.0 | nM | - |