Assay Detail
Binding
CHEMBL4193447
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Inhibition of human erythrocytic AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 180 secs by spectrophotometric analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.48 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.80 |
| CHEMBL4203538 | — | — | 1 | 5.73 |
| CHEMBL4214755 | — | — | 1 | 5.56 |
| CHEMBL3917990 | — | — | 1 | 5.53 |
| CHEMBL4217212 | — | — | 1 | 5.52 |
| CHEMBL4208392 | — | — | 1 | 5.49 |
| CHEMBL4203653 | — | — | 1 | 5.49 |
| CHEMBL3978533 | — | — | 1 | 5.34 |
| CHEMBL4214951 | — | — | 1 | 5.33 |
| CHEMBL4216806 | — | — | 1 | 5.27 |
| CHEMBL4218997 | — | — | 1 | 5.24 |
| CHEMBL4207876 | — | — | 1 | 5.19 |
| CHEMBL4212229 | — | — | 1 | 5.14 |
| CHEMBL3891025 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4203538 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4214755 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3917990 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL4217212 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4208392 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4203653 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL3978533 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL4214951 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL4216806 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL4218997 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4207876 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4212229 | — | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL3891025 | — | IC50 | = | 8320.0 | nM | 5.08 |