Assay Detail
Binding
CHEMBL4193535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by HTRF colorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.06 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765463 | — | — | 1 | 7.23 |
| CHEMBL4213353 | — | — | 1 | 7.05 |
| CHEMBL4207685 | — | — | 1 | 6.97 |
| CHEMBL4207150 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765463 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4213353 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4207685 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4207150 | — | IC50 | = | 108.0 | nM | 6.97 |