Assay Detail
Binding
CHEMBL4193702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HDAC8 (unknown origin) expressed in Escherichia coli using fluor de Lys(R) as substrate pretreated for 5 mins followed by substrate addition measured after 35 mins by fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.18 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170177 | — | — | 1 | 8.18 |
| CHEMBL4209843 | — | — | 1 | 7.36 |
| CHEMBL4208780 | — | — | 1 | 7.26 |
| CHEMBL4218293 | — | — | 1 | 7.09 |
| CHEMBL4206571 | — | — | 1 | 6.96 |
| CHEMBL4214404 | — | — | 1 | 6.72 |
| CHEMBL4218825 | — | — | 1 | 6.68 |
| CHEMBL4213891 | — | — | 1 | 6.47 |
| CHEMBL4206987 | — | — | 1 | 6.41 |
| CHEMBL4211873 | — | — | 1 | 6.32 |
| CHEMBL4210933 | — | — | 1 | 6.02 |
| CHEMBL4208365 | — | — | 1 | 5.85 |
| CHEMBL4208901 | — | — | 1 | 5.75 |
| CHEMBL4213297 | — | — | 1 | 5.72 |
| CHEMBL4217705 | — | — | 1 | 5.72 |
| CHEMBL4212751 | — | — | 1 | 5.40 |
| CHEMBL4209492 | — | — | 1 | 5.17 |
| CHEMBL4216233 | — | — | 1 | 5.00 |
| CHEMBL4206055 | — | — | 1 | 4.72 |
| CHEMBL4204967 | — | — | 1 | 4.72 |
| CHEMBL4078522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170177 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4209843 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4208780 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4218293 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4206571 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4214404 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4218825 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4213891 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4206987 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4211873 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4210933 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4208365 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4208901 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4213297 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4217705 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4212751 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4209492 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4216233 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4206055 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4204967 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4078522 | — | IC50 | > | 100000.0 | nM | - |