Compound Detail
CHEMBL4078522
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Basic Information
| ChEMBL ID | CHEMBL4078522 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PFEWRCHYOZKKDK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
2
PK Parameters
6
Publications
0
Known Names
Molecular Properties
194.2
MW (Da)
0.67
ALogP
3
HBA
3
HBD
61.4
PSA (Ų)
0.37
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase 1 CHEMBL325 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
| Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) CHEMBL2111363 | IC50 | 4.14 | 4.14 | 72000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 2.1 | hr | Rattus norvegicus |
| T1/2 | 6.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 1 | IC50 | = | 50000.0 | nM | 4.3 | Inhibition of recombinant full-length human C-terminal FLAG-His-tagged HDAC1 exp... | 28835796 |
| Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) | IC50 | = | 72000.0 | nM | 4.14 | Inhibition of recombinant human full-length C-terminal His-tagged HDAC3 (395 to ... | 28835796 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28985084 | 10.1021/acs.jmedchem.7b01444 | Plasma | 3 |
| 28835796 | 10.1021/acsmedchemlett.7b00126 | Histone deacetylase 1 | 1 |
| 28835796 | 10.1021/acsmedchemlett.7b00126 | Histone deacetylase 2 | 1 |
| 28835796 | 10.1021/acsmedchemlett.7b00126 | Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) | 1 |
| 28835796 | 10.1021/acsmedchemlett.7b00126 | Histone deacetylase 8 | 1 |
| 28835796 | 10.1021/acsmedchemlett.7b00126 | Histone deacetylase 6 | 1 |
Data from ChEMBL 36 via Core Engine